Neurotransmitters & How Drugs Affect Them

The following is a quick overview of the most common neurotransmitters and how drugs affect them.  This information is from Drugs and Society, 11th edition, by Glen Hanson and Peter Venturelli, 2012.

Neurotransmitters Type of Effect Major CNSChanges Drugs Influence
Dopamine Inhibitory­Excitatory Euphoria, Agitation, Paranoia Amphetamines and Cocaine Activates the Neurotransmitters
GABA Inhibitory Sedation, Relaxation, Drowsiness, and Depression Alcohol, Valium ­type, and Barbiturates Activates the Neurotransmitters
Serotonin Inhibitory Sedation, Relaxation, and Sleep LSD Activates the Neurotransmitters
Acetylcholine Inhibitory­Excitatory Excitation, Mild­ Euphoria, and Insomnia Tobacco and Nicotine Stimulates the Neurotransmitters
Endorphins Inhibitory Blocks Pain, Mild­ Euphoria, and Slow Respiration Narcotics Activates the Neurotransmitters

Look at how these neurotransmitters affect the Central Nervous System: evoking euphoria, sedation, and relaxation, as well as blocking pain. These are no small incentives for people.